In the game RDR 2 you will be able to find the legendary Buffalo located near lake Isabella. The Buffalo should go hunting with heavy weapons. With a rifle you can shoot things from far away, but will have to do a few shots to kill individual large size. With a shotgun you have to get close, but such a weapon is considered to be the most effective.
By itself, Buffalo is not aggressive - if he notice you, then run away. Because of this, it can simply lose. If you were able to get close to him, then you need not to hesitate and immediately shoot. A few shots at goal and the Buffalo will be defeated.
Now let's see where you can give the animal skin. If you go to hunter, get a few achievements. If you decide to go to the fence, it will make the talisman from animal horns. It helps to restore stamina of your body.
